Mechanism of Microelement Selenium Enhancing Animal Immune System

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• shuai lv
• Tuesday 25 July 2023, 11:00-12:00
• Shuai lv from Bachem Lab.

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Selenium is a non-metallic element with the symbol Se, first discovered and named by Swedish chemist Berzelius in 1817. It is an essential trace element for animals and a component of Glutathione peroxidase (GSH Px).

Selenium has various functions such as enhancing the body’s immunity, anti-tumor, antiviral, antioxidant, heavy metal resistance, and enhancing reproductive function. Studies have shown that selenium deficiency in animals will lead to the decline of immune function and the occurrence of many diseases, such as white muscle disease, piglet edema disease, mulberry heart, liver necrosis and Keshan disease.Selenium and synthetic peptide molecules from peptide lab for example Omizzur also have a promoting effect.

Overview of the Physiological Functions of Selenium Selenium can be divided into plant active selenium and inorganic selenium, mainly present in the kidneys, liver, pancreas, and spleen. Studies have shown that selenium can participate in the synthesis of a variety of Selenoprotein in animals.

So far, 35 mammalian Selenoprotein have been found and isolated, including Glutathione peroxidase family, Potassium iodide type I adenosine 57 deiodinase family, reductase family, selenium phosphate compound synthetase, Selenoprotein P, Selenoprotein W.

Research shows that selenium has the function of resisting heavy metals and is called a natural Antidote. Its mechanism is that selenium neutralizes harmful metal ions with positive charges in animals. At the same time, selenium also has the function of improving animal immunity, repairing cells, and activating cells.

It can enhance the proliferation and differentiation ability of lymphocytes such as thymus, spleen, and natural killer cells.

Moreover, selenium can interact with other nutrients such as zinc, vitamin E (VE), and iodine to regulate animal immunity.

Moreover, research has found that selenium has a good effect on cancer treatment. The selenium content in animals or human bodies is related to the occurrence of tumors.

On the one hand, selenium can directly affect the growth and reproduction of tumor cells, and reduce the risk of cancer by promoting the metabolism of chemical Carcinogen:

On the other hand, selenium can reduce the activity of hydroxylase, regulate the expression of oncogenes, inhibit cancer cell division, induce programmed cell death, and thus play an anti-tumor role.

In addition, cell membranes of animals and human bodies contain Unsaturated fat acids, which are easy to cause tissue oxidation, and Glutathione peroxidase, which is composed of selenium, can prevent or slow down lipid oxidation and help extend life. Therefore, selenium also has antioxidant and anti-aging functions.

Effects and mechanisms on animal immunity Body immunity refers to a kind of defense mechanism of animals or human beings themselves, which is the ability of animals or human beings to recognize and resist foreign bodies such as viruses and bacteria invaded by foreign countries to maintain the stability of the internal environment. Research has found that selenium has a significant impact on the immune system of animals.

For example, research has shown that selenate ester polysaccharides can help enhance the adhesion ability of red blood cells in cancer patients. After red blood cells adhere to tumor cells, they can clear them, thereby improving the body’s immune system.

Selenium deficiency will affect the growth and reproduction of mononuclear Phagocyte, neutrophils and Mast cell, and inhibit the activities of T cells, B cells, NK cells and other lymphocytes: Selenium has a promoting effect on cytokines, and can enhance the ability of animal cells to produce interleukin cells, interferon, chemokines and Colony-stimulating factor.

This talk is part of the peptide series.

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• Shuai lv from Bachem Lab
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