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Ultrasound Super-Resolution Imaging with Microbubble Contrast Agents

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Abstract — Ultrasound super-resolution imaging can be achieved by localizing spatially isolated microbubble contrast agents over multiple imaging frames. In vivo images with resolutions of circa. 10-20 microns in deep tissue have been demonstrated. The technique has the potential to revolutionize the way micro-circulation can be visualized and quantified, and has implications in a wide range of clinical applications including cancer, vascular diseases, diabetes and beyond. In this talk I will describe the principle of the technique, and some initial in vitro and in vivo results obtained through a collaboration with Imperial Physics Dept. and KCL , demonstrating the super resolution achieved compared with existing ultrasound imaging. I will also discuss the challenges and opportunities.

Bio – Dr Mengxing Tang is a Reader in Biomedical Imaging in the Department of Bioengineering, Imperial College. He joined the college in 2006 after his postdoctoral training at the Department of Engineering Science, University of Oxford and founded the Ultrasound Laboratory for Imaging and Sensing (ULIS).

Dr Tang’s current research focuses on developing new imaging and signal processing techniques using ultrasound and its allied technologies (e.g. microbubble contrast agents) for quantifying physiological flow, tissue perfusion, and molecular information, and their applications in cardiovascular diseases, cancer and neurology. His group, together with collaborators at Imperial and KCL , has been developing and applying new contrast enhanced ultrasound (CEUS) imaging techniques of very high temporal and spatial resolution and image contrast. Dr Tang has authored more than 80 peer reviewed journal papers. His research has been generously supported by the UK Engineering Physical Sciences Research Council, Cancer Research UK, British Heart Foundation, Wellcome Trust and the Royal Society, with a current funding potifolio of ~1.5M . He is an Associate Editor of the IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, and is on the Editorial Advisory Board of Ultrasound in Medicine and Biology.

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