Integrated Bio-Nano-CMOS-Sensors for Remote Monitoring of Human Metabolism in Personalized Medicine

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• Dr Sandro Carrara, EPFL - École Polytechnique Fédérale de Lausanne
• Monday 23 September 2013, 14:00-15:00
• Dennis Gabor Seminar Room (611), EEE Department.

If you have a question about this talk, please contact Wiesia R Hsissen.

Integrated Bio/CMOS interfaces for diagnosis and/or treatment of patients with specific physiological conditions (e.g., heart, cardiovascular, cancer diseases) or convalescents is a key factor to provide better, more rationale, effective and ultimately low-cost health care also at home. The ultimate goal of improved health care on those subjects is the extension of the patients’ autonomy, the possibility for auto-monitoring, the improvement of their comfort levels and their integration into everyday life. On-line monitoring is also required in professionals and recreational sportsmen training, as well as in elderly and/or disabled citizen care and/or people involved in public utilities (e.g. the public-transportation drivers). For those, it is a key aspect the maintenance of their safety by through embedded systems to alert emergency services in the event of a potentially dangerous situation. Some systems for on-line monitoring are available in the market. They use wearable devices (accelerometers, heartbeat monitoring system, etc). However, all these systems do not measure the human metabolism at molecular level (metabolites). The only available real-time, implantable/wearable systems for metabolic control are limited to glucose monitoring and used only for diabetic patients. However, many other molecules present crucial relevance in human metabolism in chronic patients. So far, there are no available integrated nano-bio-systems for multi-metabolites, real-time, remote monitoring of the human metabolism. Thus, the aim of this keynote talk is to present an innovative concept for multi-panel, highly integrated, fully implantable, remotely powered and real-time monitoring systems for human metabolism at molecular level. The considered metabolic molecules will be glucose, lactate, glutamate, ATP , and injected drugs. The proposed nanotechnology will be based on carbon nanotubes to improve the sensors performance.To pursue their detection, innovative VLSI solutions are discussed including the system remote powering. The new approach is obtained by integrating nano/bio/micro/CMOS/SW/RF systems in three devices: (i) a fully implantable sensors array for data acquisition; (ii) a on-skin intelligent-patch for remote powering and signal processing; (iii) a wearable station (a mobile phone) for data collection, elaboration and storage. The major presented breakthroughs are in the areas of: (i) nano-sensors; (ii) signal analysis; (iii) HW/Bio co-design; (iv) multi-panel metabolites detection; (v) fully implantable sensors; (vi) remote powering; (vi) minimally-invasive biomedical implants.

SHORT BIOGRAPHY : Sandro Carrara is a lecturer and scientist at the EPFL in Lausanne (Switzerland). He is former professor of optical and electrical biosensors at the Department of Electrical Engineering and Biophysics (DIBE) of the University of Genoa (Italy) and former professor of nanobiotechnology at the University of Bologna (Italy). Sandro Carrara graduated in Electronics in Technical school of Albenga, got a Master in Physics from University of Genoa and received his Ph.D. in Biochemistry and Biophysics from University of Padoa. He is founder and Editor-in-Chief of the journal BioNanoScience by Springer, Topical Editor of the IEEE Sensors Journal, and Associate Editor of IEEE Transactions on Biomedical Circuits and Systems. He is an IEEE member for the Circuit and System Society (CASS) and member of the Board of Governors of the IEEE Sensors Council. He also has been recently appointed as CASS Distinguished Lecturers for the years 2013-2014. His scientific interests are on electrical phenomena of nano-bio-structured films, and include CMOS design of biochips based on proteins and DNA . He has more then 130 scientific publications and 10 patents. He has Top-25 Hottest-Articles (2004, 2005, 2008, 2009, and 2012) published in highly ranked International-Journals such as Biosensors and Bioelectronics, Sensors and Actuators B, and Thin Solid Films. His work received a NATO Advanced Research Award in 1996 for the original contribution to the physics of single-electron conductivity in nano-particles, two Best Paper Awards at the IEEE PRIME Conference in 2010 (Berlin), and in 2009 (Cork), a Best Poster Award at the Nanotera workshop in 2011 (Bern), and a Best Poster Award at the NanoEurope Symposium in 2009 (Rapperswil). He also received the Best Referees Award from the journal Biosensor and Bioelectronics in 2006. From 1997 to 2000, he was a member of an international committee at the ELETTRA Synchrotron in Trieste. From 2000 to 2003, he was scientific leader of a National Research Program (PNR) in the filed of Nanobiotechnology. He is now an internationally esteemed expert of the evaluation panel of the Academy of Finland in a research program for the years 2010-2013. He was Chair in boards of several International Conferences such as NanoNets/Luzern-2009, IEEE -IWASI/Bari-2011, ISMICT /Montreux-2011, and of several editions of IEEE BioCAS Conference. He will be the General Chairman of the Conference BioCAS, edition 2014.

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